The drug may take up two minutes to improve symptoms of benzodiazepine toxicity. In addition to flumazenil, healthcare clinicians may also intubate the person to help open the airway and assist breathing. midazolam (used for sedation in surgery)įlumazenil is given as an intravenous (IV) infusion that inhibits the activity of benzos and reverses the binding of benzos from benzodiazepine receptors.It can also be used to reverse the postoperative effects of benzos that are used as anesthetics. Treating A Benzo Overdose With Flumazenilįlumazenil, also known as Romazicon, is a benzodiazepine antagonist, which means it reverses and blocks the effects of benzodiazepine agonists. If you suspect a loved one of experiencing a benzodiazepine overdose, seek medical attention immediately. Respiratory depression is characterized by slowed breathing and can be life-threatening if untreated.Īlong with difficulty breathing, other signs of a benzo overdose may include:

When taken in high doses, benzos can cause severe respiratory depression. These functions include breathing, heart rate, and blood pressure. However, benzos are central nervous system (CNS) depressants that slow the body’s functions. This helps increase relaxation and reduce symptoms related to anxiety and insomnia. Causes Of Benzodiazepine Overdoseīenzodiazepines (benzos) increase the neurotransmitter gamma-aminobutyric acid (GABA) after binding to benzodiazepine receptors in the brain. Flumazenil works as an antidote by inhibiting the effects of benzodiazepines on the central nervous system. Although they are generally safe to take as prescribed, large doses can result in a benzodiazepine overdose.įlumazenil is an FDA-approved medication used by medical professionals that can reverse the effects of a benzodiazepine overdose.

Benzodiazepines are a class of prescription drugs commonly used to treat anxiety and insomnia disorders.

Midazolam antidote